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Molecular epidemiology of Mycobacterium tuberculosis to describe the transmission dynamics among Inuit residing in Iqaluit Nunavut using whole-genome sequencing

2021

Alvarez, F.G., Zwerling, A.A., Duncan, C., Pease, C., Van Dyk, D., Behr, M.A., Lee, R.S., Mulpuru, S., Pakhale, S., Cameron, D.W., Aaron, S.D., Patterson, M., Allen, J., Sullivan, K., Jolly, A., Sharma, M.K., & Jamieson, F.B.

Oxford Academic

Description

In this article, the authors present findings from a study that explored the transmission dynamics of TB among Inuit in the Canadian Arctic using whole-genome sequencing of isolates from patients who had culture-positive pulmonary TB in Iqaluit between 2009 and 2015. The authors calculated the number of transmission events between cases within clusters and conducted social network analysis of the data. Findings from this study suggested that socioeconomic factors may have contributed significantly to the rise of cases in this Inuit community.

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Molecular epidemiology of Mycobacterium tuberculosis to describe the transmission dynamics among Inuit residing in Iqaluit Nunavut using whole-genome sequencing.

Alvarez, F.G., Zwerling, A.A., Duncan, C., Pease, C., Van Dyk, D., Behr, M.A., Lee, R.S., Mulpuru, S., Pakhale, S., Cameron, D.W., Aaron, S.D., Patterson, M., Allen, J., Sullivan, K., Jolly, A., Sharma, M.K., & Jamieson, F.B. (2020). Molecular epidemiology of Mycobacterium tuberculosis to describe the transmission dynamics among Inuit residing in Iqaluit Nunavut using whole-genome sequencing. Clinical Infectious Diseases, 72(12), 2187–2195.

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